NATURAL BIRTH VS CEASAREAN SECTION – (C-Section) – Scientist now have the results of a new study carried out by Yale University which was funded by the National Institute of Health.

Natural Birth - But Not Caesarean-Section - Triggers Brain-Boosting Proteins

Natural Birth - But Not Caesarean-Section - Triggers Brain-Boosting Proteins

Filed under Maternity Talk

Breaking Science News August 2012

This news is gathered from universities, journals, and other research organizations and carries the relevant citations.

Natural Birth -- But Not Caesarean-Section -- Triggers Brain-Boosting Proteins 

Science Daily (Aug. 8, 2012) — Vaginal birth triggers the expression of a protein in the brains of newborns that improves brain development and function in adulthood, according to a new study by Yale School of Medicine researchers, who also found that this protein expression is impaired in the brains of offspring delivered by caesarean section (C-sections). 

The UCP2 protein is expressed in natural birth. (Credit: Michael Helfenbein, Horvath Lab, Yale University) 

These findings are published in the August issue of PLoS ONE by a team of researchers led by Tamas Horvath, the Jean and David W. Wallace Professor of Biomedical Research and chair of the Department of Comparative Medicine at Yale School of Medicine.

The team studied the effect of natural and surgical deliveries on mitochondrial uncoupling protein 2 (UCP2) in mice. UCP2 is important for the proper development of hippocampal neurons and circuits. This area of the brain is responsible for short- and long-term memory. UCP2 is involved in cellular metabolism of fat, which is a key component of breast milk, suggesting that induction of UCP2 by natural birth may aid the transition to breast feeding.

The researchers found that natural birth triggered UCP2 expression in the neurons located in the hippocampal region of the brain. This was diminished in the brains of mice born via C-section. Knocking out the UCP2 gene or chemically inhibiting UCP2 function interfered with the differentiation of hippocampal neurons and circuits, and impaired adult behaviours related to hippocampal functions.

"These results reveal a potentially critical role of UCP2 in the proper development of brain circuits and related behaviours," said Horvath. "The increasing prevalence of C-sections driven by convenience rather than medical necessity may have a previously unsuspected lasting effect on brain development and function in humans as well."

Other authors on the study included Julia Simon-Areces, Marcelo O. Dietrich, Gretchen Hermes, Luis Miguel Garcia-Segura, and Maria-Angeles Arevalo.The study was funded by the National Institutes of Health.

Story Source :

The above story is reprinted frommaterials provided by Yale University. The original article was written by Karen N. Peart.


Note : Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference :

Julia Simon-Areces, Marcelo O. Dietrich, Gretchen Hermes, Luis Miguel Garcia-Segura, Maria-Angeles Arevalo, Tamas L. Horvath.Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult BehaviourPLoS ONE, 2012; 7 (8): e42911 DOI: 10.1371/journal.pone.0042911

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